CBD + CBN oil to sleep. With Pasiflora and blueberry aroma

Chronic sleep dysregulation involves complex, interwoven physiological mechanisms—including hyper-arousal of the central nervous system, endocannabinoid tone deficiencies, and disrupted GABAergic inhibition. This specialized sleep formulation leverages dual-cannabinoid pharmacodynamics paired with phytotherapeutic botanical co-factors to address sleep quality through complementary biochemical pathways:

Cannabinol (CBN) Sedative Modulation: Formed through the controlled oxidative degradation of tetrahydrocannabinol, purified crystalline CBN exhibits affinity for CB2 receptors while exerting subtle modulation at CB1 receptors. In clinical and pre-clinical evaluations, CBN works synergistically with CBD to enhance physical sedation, lower body temperature, and prolong restorative slow-wave sleep cycles without morning cognitive grogginess.
Cannabidiol (CBD) Anxiolytic Homeostasis: At a 10% concentration, Cannabidiol acts as an allosteric modulator of CB1, modulates 5-HT1A serotonergic receptors, and inhibits fatty acid amide hydrolase (FAAH) to elevate endogenous anandamide levels. This action mitigates somatic anxiety, reduces physical muscle spasticity, and downregulates evening autonomic stress responses.
Passiflora (Passiflora incarnata) GABA Agonism: Renowned in European phytotherapy and the European Union herbal monograph (EMA/HMPC/113556/2008), passionflower extract provides standardized bioactive flavonoids (vitexin, orientin, and chrysin). These compounds bind allosterically to the GABA-A receptor complex, amplifying native inhibitory neurotransmission to quiet cyclical thoughts and shorten sleep-onset latency.
Natural Blueberry Terpene Complex: Formulated with pure botanical and cannabis-derived terpenes dominated by myrcene (a muscle-relaxing monoterpene that enhances blood-brain barrier permeability) and linalool (a floral monoterpene alcohol that supports parasympathetic nervous activity). The natural blueberry aromatic profile eliminates bitter herbal aftertastes, ensuring optimal patient compliance during prolonged sublingual absorption.

Technical Specifications & Certificate of Analysis (CoA)

Specification	Standard / Analytical Value
Active Cannabinoid Content	Cannabidiol (CBD) 10.0% w/w + Cannabinol (CBN) 5.0% w/w
Target Cannabinoid Milligrams	1,000 mg CBD + 500 mg CBN per 10 mL (or 3,000 mg CBD + 1,500 mg CBN per 30 mL)
THC Concentration (Δ9-THC + THCA)	Non-detectable (< 0.05% w/w / Below LOQ)
Botanical Extract	Passiflora incarnata L. Fluid Extract (Standardized Flavonoids ≥ 2.0%)
Terpene & Flavor Matrix	Natural Blueberry Esters, Beta-Myrcene, Linalool, Beta-Caryophyllene
Carrier Substrate	Medium-Chain Triglycerides (MCT Oil Ph. Eur. Monograph 0868)
Physical Appearance	Clear, golden-amber liquid with violet-blueberry aroma notes
Density ( $d_{20}^{20}$ )	0.935 – 0.965 g/cm³ (Ph. Eur. 2.2.5)
Peroxide Value	≤ 5.0 meq O₂/kg (Ph. Eur. 2.5.5)
Residual Solvents	Non-detectable (Ph. Eur. 2.4.24)
Heavy Metals	Pb ≤ 0.5 ppm, Cd ≤ 0.5 ppm, As ≤ 0.5 ppm, Hg ≤ 0.1 ppm (Ph. Eur. 2.4.27)
Pesticide Residues	Non-detectable (Ph. Eur. 2.8.13 / USP 561)
Microbiological Purity	TAMC < 10² CFU/mL, TYMC < 10¹ CFU/mL, Bile-tolerant Gram-negatives absent (Ph. Eur. 5.1.8)
Manufacturing Standard	EU-GMP Part II (APIs & Standardized Oral Liquids)

Sensory & Terpene Profile Breakdown

Sweet Macerated Blueberries & Forest Fruit: Natural food-grade berry esters provide an immediate, velvety wild blueberry and dark berry note that masks botanical bitterness without added sugars or artificial sweeteners.
Calming Floral Lavender: Linalool introduces a delicate floral undertone reminiscent of fresh lavender blossoms, known for its tranquilizing aromatic properties.
Earthy Herb & Musk: High concentrations of Beta-Myrcene deliver a warm, grounding herbal back-note that complements the natural woody undertones of passionflower.
Warm Spiced Clove & Cedar: Beta-Caryophyllene provides an earthy, peppered finish that anchors the fruit top notes and facilitates clean palate absorption.
Sublingual Dropper Dynamics: Formulated for smooth mucosal retention. Low kinematic viscosity allows seamless, consistent micro-dosing (~5 mg CBD + 2.5 mg CBN per standardized drop).

CBD Sleep Tincture: Organic Nighttime Relief | Lovewell Farms

10 mg/mL THC, 12-15 mg/mL CBD Medical Cannabis Oil: Hybrid (Blue ...

European Compliance, Quality Assurance & Distribution

EU-GMP Certified Formulation & Fill: Homogenized, filtered, and bottled inside certified pharmaceutical cleanroom suites operating under EU-GMP Part I & II guidelines for oral pharmaceutical solutions.
Non-Narcotic Regulatory Clearance: Formulated with non-detectable THC (< 0.05% w/w), placing this product entirely outside statutory narcotics scheduling (such as the German CanG/BtMG, UK Misuse of Drugs Act, and Austrian Narcotic Substances Act), enabling simplified, frictionless cross-border distribution across all EU/EEA member states.
Accredited Laboratory Testing: Every production lot is paired with comprehensive third-party ISO/IEC 17025 accredited Certificates of Analysis (CoAs) verifying cannabinoid potency, flavonoid marker standardization, absence of residual extraction solvents, heavy metals, and full microbiological safety.
Medical Packaging Integrity: Dispensed in amber Type III hydrolytic pharmaceutical glass vials equipped with calibrated, child-resistant, tamper-evident dropper closures (DIN 18). Packaged under inert nitrogen gas displacement to eliminate head-space oxygen and protect volatile monoterpenes and polyphenols throughout its 24-month shelf life.